My Synbiotic 365 Review (2023) – Scam/Worth The Complaints?

It’s time for my Synbiotic 365 review – a probiotic that looks very promising.

But is it really working? Not in all cases:

  • slightly pricey
  • not suitable for everyone
  • enough side reactions

So let's find out if the supplement works wonders by looking into all its hidden details.

Note: This review is based on my opinion + research on Synbiotic 365.

Review Summary

Full Name: Synbiotic 365™ by Nature M.D.™

Product Type: Probiotics

Best Actual Price: Around $45

Cheapest Place To Buy: Its fficial website

Designed For: Supporting gut health and weight management.

My Rating: 8 out of 10

Recommended?: Yes and no – and that's because of some red flags:

  • bothering side effects
  • can be pricey
  • several complaints

If you're looking for a better alternative, check out the best probiotic from the market that I know.


What I Liked About It

  • Contains various bacterial strains
  • Also contains vitamins
  • Comes with a professional site
  • A lot of info available about it
What I Didn’t Like About It

  • Cause adverse effects quite often
  • Not suitable for all users
  • Too pricey
  • Limited customer reviews



Synbiotic 365 In A Nutshell

Honestly – Synbiotic 365 is a very good supplement.

That's why there isn't much to criticize about it overall.

Its formula is good, compared to other supplements:

  • contains vitamins and herbal extracts
  • 14 probiotics
  • 20 billion CFU

But even so, some people ended up having heart palpitations.

Now – I'm not saying that it's bad supplement just because of these issues.

Just keep in mind that not everyone can tolerate it (given its pretty high dose).

For the price of $45 for 30 capsules, it's not a bad option for short-term use.

If you plan on taking it for a long time, I would think twice.

That's because the dose is quite high for a 6 months treatment, in my view.

So it may actually worsen your digestive issues, in this case (especially if you don't lack good bacteria).

But overall – Synbiotic 365 is not a bad product at all.

Still, there are some other options (which I consider much better).




#1 – Claims & Producer

Here are the first things you should know about Synbiotic 365:

  • the health problems it solves
  • how it works
  • who is the company behind
1. Claims

The supplement claims to be a “3-in-one gut health solution”:

  • improves digestive health and immunity
  • manages weight
  • supports metabolism

The other claims say that the product is non-GMO and allergen-free.

Also – the supplement is made as delayed-release gel capsules and no refrigeration is needed.

Now, I would say that these claims are realistic and straight to the point.

So Synbiotic 365 really seems like a potent product.

2. Company Behind

Synbiotic 365 is made by the brand Nature M.D.

So far – here's what I found from its website:

  • all products are designed for gut and digestive health
  • there's contact info available (email and phone number)
  • social media links are also posted on the website

I also searched for the reviews about the company and I found some complaints:

  • products being shipped very late
  • rude customer service

Overall – I would say that it's up to you whether you buy from this brand or not.

It doesn't seem like a doubtful company – but its complaints can be an issue.


#2 – Ingredients (9 out of 10)

Synbiotic 365 has a very good formula, to be honest – because it contains some very varied ingredients:

  • vitamins
  • 14 bacterial strains
  • 20 billion CFU
  • plant-based ingredient

Now – let's take a look at the vitamins inside it, for the beginning:

  1. Thiamin – prevents complications in the stomach, intestines etc. [1]
  2. Riboflavin – helps break down proteins, fats and carbohydrates
  3. Niacin – lowers and treats cholesterol
  4. Vitamin B6 – supports the nervous system and metabolism [2]
  5. Folate – maintains red blood cells count
  6. Vitamin B12 – keeps nerve cells healthy
  7. Biotin – boosts the health of hair, skin and nails
  8. Pantothenic acid – helps convert food to energy

If you notice, most of the vitamins present are just different forms of vitamin B.

Now – the bacterial strains listed below make up the probiotic blend:

  1. Lactobacillus gasseri – suppresses harmful bacteria [3]
  2. L. plantarum – increases gut population
  3. Bacillus subtilis – prevents inflammation in the gut[4]
  4. B. bifidum – treats irritable bowel syndrome
  5. Bifidobacterium lactis – helps with healthy digestion [5]
  6. B. longum – hinders the cultivation of bad bacteria
  7. Lactobacillus casei – prevents and treats diarrhea
  8. L. paracasei – improves immune function
  9. Lactobacillus rhamnosus GG – fights off bad bacteria 
  10. L. reuteri – strengthens intestinal barrier
  11. Lactobacillus salivarius – avoids and treats infection
  12. Streptococcus thermophilus – balances the number of good bacteria [6]
  13. L. fermentum – helps lose weight and belly fat [7]
  14. Saccharomyces boulardii – fights off disease-causing organisms in the gut [8]

Lastly – the final ingredient on the list is Chicory root inulin.

Its role inside the stomach is to provide fibers and to suppress appetite. [9]

Overall – the formula and ingredients are quite a lot, which is actually the ideal.

But there are high chances that not everyone can digest it properly.


If you ask me, the formula of Synbiotic 365 is really promising.

The only downside I could see is that it might be too concentrated for some users.

Some people can tolerate the strength and others can't.

But all in all, it's really strong and potent.



#3 – Pills & Dosage (6 out of 10)

Let me give some of the basic things you need to know about Synbiotic 365.

1. Pills

Here's I would simply describe the supplement:

  • light beige color
  • normal capsule size
  • usual probiotic smell

Overall – I would say that the product looks very normal to me.

So for anyone who is taking medicine on a daily basis, these pills won't be a problem.

2. Dosage

Now – I haven't really found an exact usage instruction for Synbiotic 365.

But based on the supplement facts, the serving size is one capsule.

So I would say that you can take a capsule per day, which is very easy and convenient.

My personal advice is to take it after a meal, in order to avoid stomach cramps.

But overall – I would say that the supplement is quite easy to consume.



#4 – Results (6 out of 10)

I checked out the reviews of Synbiotic 365's previous buyers.

The main goal was to see how it works for different people.

Now, the product has limited authentic customer reviews, which can be a downside.

Note: I only analyzed authentic reviews, not promotional or fake ones.

1. Positive Opinions

The only place where I found authentic reviews is on Amazon.

So far – these are the good comments I encountered:

  1. Many users experienced improvements in their bowel movement.
  2. Some said that it balancesd their gut health.
  3. The rest said that it's a quality product.

Now, the product got a rating of 4.4/5 stars (even with limited customer comments).

So it's safe to assume that it's a good supplement with a potent effect.

2. Negative Opinions

Now – let's talk about why other buyers didn't it at all:

  1. Most experienced irregular heartbeat rhythms.
  2. A lot of previous buyers said that the price is a little too high.
  3. Others complained about poor customer service.

Now – the negative comments are very few, but they are something to think about.

And I'm mostly speaking in terms of side effects.

This supplement surely works – but it also has a higher risk of secondary reactions.

So I suggest you to read and analyze it in details deciding to make the purchase.


The only thing I could say is that the results vary on different users.

Some can take tolerate the product – while  other experienced negative reactions.

So I personally wouldn't buy Synbiotic 365.

It's surely a great product, but it comes with a high risk of issues.

That's why I prefer something on the safer side.




#5 – Side Effects (5 out of 10)

As of now, I haven't found a lot of different side effects.

The only complaints I found were about heart palpitations (which are something serious).

And in my view – they are probably because of the pretty high doses.

But if you ask me, here are other adverse effects that might also happen:

  • constipation
  • diarrhea
  • gas/bloating

Also – an allergic reaction can also happen (if you're sensitive to chicory root).

But other than that, Synbiotic 365 isn't the safest product out there.


#6 – Price (5 out of 10)

If you ask me, Synbiotic 365 can get expensive in a long run.

So it's not a practical choice if you plan to take it for a long-term purpose.

1. The Exact Price

The only place where I saw different bundles for the supplement is on Nature MD's website.

So here's the price list of Synbiotic 365:

  1. 1 Box costs $45
  2. 3 Boxes cost $119
  3. 6 Boxes cost $229
  4. Offers Free Shipping
  5. 60-day Money Back Guarantee

But if you plan on subscribing, you'll get discounted prices:

  1. 1 Box costs $39
  2. 3 Boxes cost $110
  3. 6 Boxes cost $200

If you ask me, my first impression is that the price is quite reasonable for its value.

However – if the supplement will take a long time to work as you like it to be, it will be pricey.

So it's up to you if you have the budget to try it or not.

2. Competitors’ Price

Now, if you're looking for an option that works too, check my top recommended probiotic.

The supplement is called Your Biology Gut+:

  1. Your Biology Gut+ has 10 essential bacterial strains with some potent doses.
  2. The overall formula really focuses on treating digestive issues.
  3. Synbiotic 365 contains 14 bacterial strains and vitamins.
  4. The formulation also has the right doses but it can be too much for others.
  5. Your Biology Gut+ has lower chances of causing adverse reactions.
  6. While Synbiotic 365 can cause side effects more often.
  7. Your Biology Gut+ costs $64.99 on a normal basis but can be bought for only $39.
  8. Synbiotic 365 starts at around $45 and discounts upon subscription.

Honestly – both products are good for the digestive system.

However, not everyone has a strong tolerance to probiotics so that's where you should decide.

So if you want to play safe with your option, I suggest you try Your Biology Gut+.


If you notice, both products are in the same price range.

But I would say that Your Biology Gut+ won't be expensive in the long term.

And that's because it acts fast to aid digestion problems.

Meanwhile, if you take Synbiotic 365 for constant weight management, it can be very expensive.




#7 – Final Conclusions

Here’s how I would like to list down my points about Synbiotic 365:

1. Promising Formula

To be honest – Synbiotic 365 has a very good formulation:

  • 14 bacterial strains
  • Chicory root
  • Vitamins
  • 20 billion CFU

Compared to other supplements, it's one of the better options you can get.

But it's still better if you know your tolerance when it comes to probiotics.

2. Side Effects

Now – no matter how good the formula is, it's still not for everyone.

Adverse reactions are quite common from almost any supplement.

But for Synbiotic 365, you need to watch out for palpitations.

It's always better to consult a physician first so you'll know if the product suits you or not.

3. Pricey

The price of Synbiotic 365 is reasonable for its quality.

But if you plan on taking it on a long-term basis, it can get very expensive.

Most especially if you'll take it to aid weight management instead of probiotic treatment.



My Verdict – Worth It Or Not?

Short answer: Yes and no – due to the following reasons:

  1. Has vitamins and plant-based ingredient
  2. Contains 14 bacterial strains
  3. High CFU
  4. Triggers irregular heartbeat rhythm
  5.  Expensive for long-term use
  6. Not for all

Synbiotic 365 is not a bad product, in fact, it's one of the good ones.

But you just have to know first if your tolerance fits the formulation.

I suggest you consult your physician first to avoid possible side effects.

If you let me, I want to recommend something else.

The product is called Your Biology Gut+:

  • Acts quick to address digestion problems
  • Contains a variation of 10 essential probiotics with wonderful benefits
  • Works really well, fast and very effective

Both products have amazing benefits to offer that can really help you.

But if you ask me, I would tell you to choose Your Biology Gut+, if you want quick results.


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Written by 

Paula has a background in Chemistry and continues to pursue further studies in it. She loves searching for the best products in the market that will give excellent benefits to the human body and share them with you.

Last updated: March 11, 2024

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